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A: GTP cyclohydrolase I (GTPCH I) enzymatic activity in small mesenteric arteries (n = 6–7) from NORM, ANG, ANG + TT, and ANG + BH4. *Significant difference vs. NORM (P ≤ 0.05). †Significant difference vs. ANG (P ≤ 0.05). #Significant difference vs. ANG + TT (P ≤ 0.05). B: representative Western blot and relative densitometry analysis of GTPCH I protein expression normalized to β-actin in small mesenteric arteries (n = 3) from NORM, ANG, ANG + TT, and ANG + BH4.
