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. 2011 Mar 7;108(12):4788–4793. doi: 10.1073/pnas.1100844108

Fig. 5.

Fig. 5.

Model of Ulk1 phosphorylation in response to nutrients. When cells are fed, Ulk1 is hyper-phosphorylated at serine 638 and serine 758. Upon starvation, serine 638 is firstly dephosphorylated; then followed by dephosphorylation at serine 758. Dephosphorylation of Ulk1 leads to dissociation of Ulk1/AMPK. When cells are replenished with rich medium, mTOR is activated; it phosphorylates serine 638 and serine 758. The phosphorylation of Ulk1 at serine 758 then leads to reassociation between Ulk1 and AMPK. When in close proximity, AMPK functions to maintain phosphorylation Ulk1 at serine 638.