Fig. 2.

Cerebrovascular effects of Aβ_1–40 superfusion are not observed in CD36^0/0 mice. In CD36^wt/wt mice, both Aβ_1–40 (5 μM) and AngII (50 nM) attenuate resting CBF (A) and dampen the increase in CBF evoked by whisker stimulation (B) or ACh (10 μM) (C). (A–C) In CD36^0/0 mice, Aβ_1–40 does not attenuate vascular responses, whereas AngII does. (D) CBF response to adenosine (400 μM) is not affected in either group. LDU, relative laser-Doppler perfusion units; Veh, vehicle. n = 5 per group. *P < 0.05 from Veh by ANOVA, and Tukey's test.