Fig. 3.

Cerebrovascular effects of i.c. infusion of Aβ_1–40 are prevented by CD36 blocking antibodies and are not observed in CD36^0/0 mice. In CD36^wt/wt mice, i.c. infusion of Aβ_1–40 (1 μM, 150 μL/h) attenuates the increase in CBF induced by whisker stimulation (B) or ACh (C) but not by adenosine (D). (A–C) Anti-CD36 antibodies do not affect resting CBF or baseline cerebrovascular responses but prevent the dysfunction induced by Aβ_1–40. (A–D) Control (Con) IgG had no effect. The cerebrovascular dysfunction is not observed in CD36^0/0 mice. n = 5 per group. *P < 0.05 from no treatment by ANOVA and Tukey's test.