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. 2011 Mar 7;108(12):5063–5068. doi: 10.1073/pnas.1015413108

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Fig. 4. — Tg2576 mice lacking CD36 are protected from the neurovascular dysfunction. (A and B) Increase in CBF evoked by whisker simulation or ACh is attenuated in Tg2576 mice expressing WT CD36. These cerebrovascular responses are not altered in Tg2576 mice lacking CD36, however. (C) CBF responses produced by adenosine are not affected in all groups of mice. (D) Brain concentrations of SDS-soluble and SDS-insoluble (Inset) Aβ_1–40 and Aβ_1–42 are comparable in Tg2576 mice expressing WT CD36 (Tg2576/CD36^wt/wt) and lacking CD36 (Tg2576/CD36^0/0). n = 5–6 per group. *P < 0.05 from transgene-negative CD36^wt/wt, Tg2576-CD36^0/0, and transgene-negative CD36^0/0 by ANOVA and Tukey's test.