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. 2011 Mar 7;108(12):5063–5068. doi: 10.1073/pnas.1015413108

Fig. 6.

Fig. 6.

Aβ1–40-induced endothelial oxidative stress requires CD36. (A–C) CD36 is expressed in CD31+ cerebral endothelial cell cultures (bEND.3). (D) In these cultures Aβ1–40 (300 nM) but not scrambled Aβ1–40 (scAβ1–40, 300 nM) or Aβ1–42 (5 μM) increases the ROS signal, an effect attenuated by the ROS scavengers MnTBAP (30 μM) and PEG-SOD (50 U/mL) or by the NADPH oxidase peptide inhibitor gp91ds-tat (1 μM). (E) Increase in ROS induced by Aβ1–40 but not AngII (1 μM) is attenuated by CD36 blocking antibodies (Anti-CD36; 2.5 μg/mL) but not control (Con) IgG.(Scale bar: 50 μm.) RLU, relative fluorescent light unit. n = 18–50 cells per group. *P < 0.05 (significantly increased from no treatment); #P < 0.05 (significantly decreased from no treatment) by ANOVA and Tukey's test.