Table 3.
Treatment | Animal | Graft survival, days | Histology at week*
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||||
None | 13384 | 7 | Interstitial†: | 4 | |||||||
Vascular‡: | 0 | ||||||||||
None | 13896 | 7 | Interstitial: | 4 | |||||||
Vascular: | 0 | ||||||||||
CyA‡ | 13262 | 59 | Interstitial: | 1b | 3b | 1b | 3b | ||||
Vascular: | 0 | 0 | 0 | 3 | |||||||
CyA | 13397 | 53 | Interstitial: | 3a | 3b | 4 | |||||
Vascular: | 0 | 0 | 3 | ||||||||
CyA | 13495 | 52 | Interstitial: | 3a | 4 | ||||||
Vascular: | 0 | 3 | |||||||||
PC14 #1–3 + CyA | 13511 | 8 | Interstitial: | 4 | |||||||
Vascular: | 2 | ||||||||||
PC14 #1–3 + CyA | 13692 | 5 | Interstitial: | 4 | |||||||
Vascular: | 3 | ||||||||||
PC14 #1–3 + CyA | 14071 | 4 | Interstitial: | 4 | |||||||
Vascular: | 1 | ||||||||||
PC14 #1–3 + CyA | 14311 | 5 | Interstitial: | 4 | |||||||
Vascular: | 3 | ||||||||||
DRβ1c + CyA | 13914 | >60 | Interstitial: | 3a | 3a | 3a | 3a | 3a | 3a | ||
Vascular: | 0 | 0 | 0 | 0 | 0 | 0 | |||||
DRβ1c + CyA | 14146 | >30 | Interstitial: | 3a | 3b | 3b | |||||
Vascular: | 0 | 0 | 0 |
Last datapoint in each row represents the postmortem specimen.
Grading based on the scoring system presented in Results.
CyA 10–13 mg/kg IV on POD 0–11.