Table 2.
Effect of TRC150094 on glycemic parameters in male obese ZSF1 rats
| Parameter | Treatment week | Control |
TRC150094 6 mg/kg |
TRC150094 12 mg/kg |
|---|---|---|---|---|
| Fasting plasma glucose (mg/dL) | 0 | 286.3 ± 16.7 | 292.7 ± 17.4 | 280.6 ± 15.8 |
| 6 | 328.2 ± 20.4 | 299.3 ± 24.3* | 250.4 ± 21.9*, # | |
| 16 | 294.6 ± 15.1 | 243.6 ± 14.5*, # | 269.2 ± 10.9 | |
| 24 | 232.6 ± 15.0 | 193.8 ± 15.1*, ## | 206.5 ± 9.2*** | |
| Random plasma glucose (mg/dL) | 0 | 490.8 ± 13.0 | 500.7 ± 14.8 | 488.9 ± 11.1 |
| 5 | 494.2 ± 16.0 | 454.9 ± 20.0 | 433.4 ± 23.8 | |
| 24 | 364.9 ± 30.7 | 303.2 ± 27.8*** | 317.9 ± 29.5*, ## | |
| AUCglucose during OGTT (mg*h/dL) |
0 | 977.8 ± 31.0 | 952 ± 29.1 | 930.0 ± 29.9 |
| 6 | 997.6 ± 32.5 | 886.5 ± 36.8*, # | 813.9 ± 68.9*, # | |
| 24 | 726.1 ± 38.7 | 568 ± 24.5**, # | 554.9 ± 50.6*, # | |
| Fructosamine (μmol/L) | 24 | 345.5 ± 57.0 | 354.1 ± 41.1 | 252.3 ± 23.2***, ## |
Notes: Values are mean ± SEM.
*
P < 0.05;
**
P < 0.01;
***
P < 0.1 vs control group (Student’s t-test);
#
P < 0.05;
##
P < 0.1 vs control (ANOVA followed by Dunnett’s post hoc test), n = 8–10.
Abbreviations: ANOVA, analysis of variance; AUCglucose, area under the glucose response curve; OGTT, oral glucose tolerance test; SEM, standard error of mean.