Table 3.

Effect of TRC150094 12 mg/kg/d treatment on liver and skeletal muscle mitochondrial parameters in male obese ZSF1 rats

Parameter	Liver		Skeletal muscle
	Control	Treated	Control	Treated
Respiratory parameters
State 4 respiration (nmol/mg/min)	54.1 ± 8.2	68.1 ± 6.3	67.8 ± 12.7	104.7 ± 11.35*
State 3 respiration (nmol/mg/min)	193.5 ± 17.5	260.4 ± 22.0*	198.4 ± 28.8	301.86 ± 20.94*
Fatty acid oxidation (FAO)
FAO/palmitoyl CoA (nmol/mg/min)	29.3 ± 2.1	37.3 ± 3.9*	28.9 ± 5.2	36.96 ± 7.66
FAO/palmitoyl carnitine	39.3 ± 5.3	53.9 ± 3.1*	42.7 ± 2.2	62.4 ± 6.3**
CPT activity (nmolCoA/mg/min)	23.98 ± 3.0	28.13 ± 1.5	17.6 ± 2.7	21.23 ± 3.8

Notes: Values are mean ± SEM (standard error of mean).

^*P < 0.05;

^**P < 0.01 vs control group (n ≥ 5).

Abbreviations: CoA, coenzyme A; CPT, carnitine palmitoyl transferase; SEM, standard error of mean.