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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: Pharm Res. 2008 Mar 4;25(9):2135–2142. doi: 10.1007/s11095-008-9553-z

Fig. 2.

Fig. 2

Effect of GTP infusion on RANK and NIK in the dorso-lateral prostate of TRAMP mice during progressive stages of PCa development. Protein levels by immunoblot analysis of A RANK and B NIK. As detailed in “MATERIALS AND METHODS”, the protein levels were determined in the dorso-lateral prostate of 8-, 16-, 24-, and 32-week-old control (water-fed) and treated (GTP-fed) TRAMP mice along with their age matched non-transgenic littermates. Equal loading of protein was confirmed by stripping the blot and re-probing with β-actin antibody. Western blot analysis was conducted in five animals in each group, and only representative blots are shown. Histogram represents relative density data of the immunoblots in relative units ± SEM normalized to β-actin. *P<0.05; compared with water-fed TRAMP mice of the preceding age. **P<0.001 compared with age matched water-fed TRAMP mice.