Table 2.
Maximal relaxation responses and EC50 values of vessels incubated with acetylcholine to Ach of mesenteric arteries from vehicle, Ang II, tempol, tempo with Ang II infusion rats
Response | Maximum (%) | Maximum (%) | P | Log EC50 (mol/L) | Log EC50 (mol/L) | P |
---|---|---|---|---|---|---|
Vehicle | Ang II | |||||
Ach | 83.9 ± 7.9 | 36.0 ± 7.0 | <0.01 | −6.17 ± 0.06 | −5.47 ± 0.04 | <0.005 |
EDRF | 54.4 ± 4.6 | 18.0 ± 4.7 | <0.01 | −6.55 ± 0.06 | −5.78 ± 0.05 | <0.005 |
EDHF | 29.4 ± 2.7 | 18.7 ± 2.7 | <0.05 | −5.18 ± 0.07 | −5.46 ± 0.16 | ns |
EDCF | 5.2 ± 4.6 | 23.0 ± 5.6 | <0.05 | −4.11 ± 0.35 | −4.49 ± 0.03 | <0.005 |
Tempol | Tempol-Ang II | |||||
Ach | 88.9 ± 7.9 | 69.9 ± 8.9 | ns | −6.21 ± 0.05 | −6.16 ± 0.08 | ns |
EDRF | 53.4 ± 5.7 | 41.4 ± 4.7 | ns | −6.76 ± 0.09 | −6.67 ± 0.01 | ns |
EDHF | 35.4 ± 3.7 | 27.4 ± 4.7 | ns | −5.38 ± 0.15 | −5.15 ± 0.14 | ns |
EDCF | 5.1 ± 6.2 | 10.4 ± 4.6 | ns | −4.16 ± 0.13 | −4.44 ± 0.07 | ns |
Data were obtained from experiments described in Figure 1.