Table 3.

Summary of Non-Dose Limiting Toxicities Observed in 16 Evaluable Patients

	Cycle 1 (16 total cycle)				Cycle 2 to 7 (15 total cycles)
	Maximum grade across cycle1				Maximum grade, cycle 2 to 6
Hematologic Toxicity	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
Anemia	3	2		1	2	1
Leukopenia	5	1				1	1
Lymphopenia	4	1		1	2		1
Neutropenia	1					1	1	1
Thrombocytopenia	6	2			2			1
Non-Hematologic Toxicity*
Somnolence		1
Fatigue	3	2				1
Nausea	1		1
Vomiting		2
Hypoalbuminemia	1	2
Dizziness	4				1
Headache	1	1				1

^*only non-hematologic toxicities related to protocol therapy occurring in more than 10% of patients during the first cycle of VPA are listed