FIG. 1.

Curcumin reduces (A) total intestinal polyp number and (B) polyp number in all size categories [>2 mm (large), <2 mm, >1 mm (medium), and <1 mm (small)] in the Apc^Min/+ mouse model of intestinal tumorigenesis (n = 10/group). Mice were fed a placebo or curcumin diet from 4 to 18 weeks of age. After the treatment period mice were sacrificed and polyps were counted in sections 1 and 4 of the small intestine and the colon (section 5) and categorized as >2 mm, 1–2 mm, and <1 mm. Values are means ± standard error of the mean (SEM). *Significantly different from placebo, P < 0.05.