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. 2011 Mar 25;6(3):e18097. doi: 10.1371/journal.pone.0018097

Figure 1. CAB induces apoptosis of anterior pituitary cells in an E2-dependent manner.

Figure 1

OVX and E2 treated rats were injected with CAB (1 mg/kg, ip) or vehicle (CONTROL) and euthanized 16 h later. Anterior pituitary cells were dispersed and apoptosis was detected by Annexin-V and flow cytometry. Each column represents the mean ± SE of the percentage of apoptotic cells (n = 8 rats/group). Data were analyzed by two-way ANOVA, followed by Tuckey's test. *p<0.05 vs. respective control without CAB, ∧p<0.05 vs respective control without E2.