Table 1.
Total cohort (N = 361) |
Five-year survivors (N = 240) |
|||
---|---|---|---|---|
n | % | n | % | |
Age at diagnosis | ||||
0–4 | 122 | 33.8 | 82 | 34.2 |
5–9 | 118 | 32.7 | 80 | 33.3 |
10–20 | 121 | 33.5 | 78 | 32.5 |
Gender | ||||
Male | 196 | 54.3 | 137 | 57.1 |
Female | 165 | 45.7 | 103 | 43.9 |
Race/ethnicity | ||||
Non-Hispanic, white | 281 | 77.8 | 194 | 80.8 |
Non-Hispanic, black | 69 | 19.1 | 41 | 17.1 |
Hispanic | 5 | 1.4 | 2 | 0.8 |
Other | 6 | 1.7 | 3 | 1.3 |
Tumor location | ||||
Diencephalon | 147 | 40.7 | 97 | 40.4 |
Hypothalamus/chiasmatic | 101 | 28.0 | 76 | 31.7 |
Thalamic | 43 | 11.9 | 20 | 8.3 |
Other | 3 | 0.8 | 1 | 0.4 |
Cerebellum | 94 | 26.0 | 61 | 25.4 |
Cerebral hemisphere | 56 | 15.5 | 38 | 15.8 |
Frontal lobe | 15 | 4.2 | 10 | 4.1 |
Temporal lobe | 28 | 7.8 | 20 | 8.3 |
Parietal lobe | 7 | 1.9 | 4 | 1.7 |
Occipital lobe | 2 | 0.6 | 2 | 0.8 |
Other | 4 | 1.1 | 2 | 0.8 |
Brainstem/spinal cord | 64 | 17.7 | 44 | 18.3 |
Extent of resection of primary surgery | ||||
<Gross total | 195 | 54.0 | 121 | 50.4 |
Gross total | 117 | 32.4 | 81 | 33.8 |
No surgery | 49 | 13.6 | 38 | 15.8 |
Extent of resection of any surgery | ||||
<Gross total | 190 | 52.6 | 114 | 47.5 |
Gross total | 145 | 40.2 | 105 | 43.8 |
No surgery | 26 | 7.2 | 21 | 8.8 |
Primary treatment type | ||||
Surgery only | 211 | 58.5 | 145 | 60.4 |
Surgery + RT | 57 | 15.8 | 38 | 15.8 |
Surgery + chemo | 34 | 9.4 | 14 | 5.8 |
Surgery + RT + chemo | 10 | 2.8 | 5 | 2.1 |
No Surgery | 49 | 13.6 | 38 | 15.8 |
No surgery, chemo, or RT | 35 | 9.7 | 29 | 12.0 |
Chemo only | 9 | 2.5 | 6 | 2.5 |
RT only | 4 | 1.1 | 3 | 1.2 |
Chemo + RT | 1 | 0.3 | 0 | 0.0 |
Any treatment type | ||||
Surgery only | 165 | 45.7 | 110 | 45.8 |
Surgery + RT | 83 | 23.0 | 67 | 27.9 |
Surgery + RT + chemo | 56 | 15.5 | 31 | 12.9 |
Surgery + chemo | 31 | 8.6 | 11 | 4.6 |
No surgery | 26 | 7.2 | 21 | 8.8 |
No surgery, chemo, or RT | 5 | 1.4 | 4 | 1.7 |
Chemo only | 8 | 2.2 | 4 | 1.7 |
RT only | 6 | 1.7 | 6 | 2.5 |
Chemo + RT | 7 | 1.9 | 7 | 2.9 |
Histology | ||||
Astrocytoma, pilocytic | 229 | 63.4 | 157 | 65.4 |
Astrocytic tumor, NOS | 34 | 9.4 | 18 | 7.5 |
Astrocytoma, fibrillary | 33 | 9.1 | 15 | 6.3 |
Oligodendroglioma | 29 | 8.0 | 22 | 9.2 |
Glioma, optic | 27 | 7.5 | 23 | 9.6 |
Astrocytoma, pylomyxoid | 5 | 1.4 | 3 | 1.3 |
Oligoastrocytoma | 4 | 1.1 | 2 | 0.8 |
Treatment era | ||||
1985–1996 | 169 | 46.8 | 124 | 51.7 |
1997–2007 | 192 | 53.2 | 116 | 48.3 |
Vital status | ||||
Alive | 317 | 87.8 | 230 | 95.8 |
Dead | 44 | 12.2 | 10 | 4.2 |
Progression status | ||||
Never progressed | 223 | 61.8 | 146 | 60.8 |
Single progression (only) | 75 | 20.8 | 48 | 20.0 |
Multiple progression | 63 | 17.5 | 46 | 19.2 |
Neurofibromatosis type 1 | ||||
No | 325 | 90.0 | 212 | 88.3 |
Yes | 36 | 10.0 | 28 | 11.6 |
RT, radiation therapy ; NOS, not otherwise specified.