Table 2.
Comparison of fibrinolytic PAI-1 and tPA between normal, non-diabetic metabolic syndrome, type 2 diabetes with and without metabolic syndrome and total type 2 diabetes groups
| Parameters | Normal (n = 131) | Non-diabetic MetS (n = 101) | Type 2 diabetes | Total Type 2 diabetes (n = 303) | |
|---|---|---|---|---|---|
| without MetS (n = 76) | with MetS (n = 227) | ||||
| PAI-1 activity (IU/ml) | 12.8(11.1-14.7) | 28.7(25.1-32.8) | 11.0(9.37-12.9) | 29.0(26.1-32.1) | 21.7(19.7-23.9) |
| p-value | a3.0 × 10-15, c1.5 × 10-18 | a0.167 | a9.8 × 10-19, c1.8 × 10-21 | a1.7 × 10-8, b0.02 | |
| PAI-1 antigen (ng/ml) | 30.2(27.1-33.7) | 33.0(29.7-36.6) | 18.2(16.2-20.6) | 28.4(26.5-30.5) | 25.4(23.9-27.1) |
| p-value | a0.259 | a2.2 × 10-9, b6.9 × 10-13 | b0.02, c5.1 × 10-10 | a0.01, b4.7 × 10-5 | |
| tPA activity (U/ml) | 3.49(3.11-3.92) | 3.51(3.14-3.91) | 3.91(3.42-4.47) | 2.82(2.58-3.07) | 3.11(2.89-3.34) |
| p-value | a0.965 | a0. 206 | a0.003, b0.002, c6.7 × 10-5 | a0.03, b0.03 | |
| tPA antigen (ng/ml) | 4.62(4.10-5.21) | 5.99(5.35-6.70) | 9.15(8.04-10.4) | 9.85(9.14-10.6) | 9.67(9.07-10.31) |
| p-value | a0.002 | a1.3 × 10-13, b1.3 × 10-6 | a8.9 × 10-24, b1.3 × 10-12 | a3.0 × 10-24, b1.7 × 10-12 | |
| tPA/PAI-1 complex (ng/ml) | 3.50(2.89-4.23) | 3.57(2.97-4.30) | 2.59(2.09-3.20) | 3.91(3.46-4.42) | 3.52(3.17-3.92) |
| p-value | a0.879 | a0.04, b0.02 | a0.336, c0.001 | a0.94 | |
The result presented as geometric mean and 95% confidence interval of mean adjusted for age, gender and race, avs control group: bvs non-diabetic metabolic syndrome group: cvs type 2 diabetes without metabolic syndrome which evaluated by univariate (General Linear Model). Bolt values are significant. MetS: metabolic syndrome.