Table 3.
Association of fibrinolytic PAI-1 and tPA with metabolic syndrome parameters among normal subjects (n = 131)
| Metabolic syndrome Parameters | PAI-1 activity b (P-value) |
PAI-1 antigen b (P-value) |
tPA activity b (P-value) |
tPA antigen b (P-value) |
|---|---|---|---|---|
| Body Mass Index (kg/m2) | 1.199 (0.001) | 1.079 (0.199) | -1.109 (0.104) | -1.021 (0.783) |
| Waist circumference (cm) | 1.159 (2.2 × 10-4) | 1.057 (0.213) | -1.033 (0.496) | -1.035 (0.543) |
| Diastolic Blood Pressure (mmHg) | -1.038 (0.342) | -1.014 (0.763) | 1.064 (0.185) | 1.028 (0.607) |
| Systolic Blood Pressure (mmHg) | -1.009 (0.846) | 1.007 (0.889) | 1.074 (0.198) | 1.084 (0.195) |
| Triglyceride (mmol/l) | 1.119 (0.165) | -1.012 (0.899) | 1.064 (0.558) | 1.127 (0.331) |
| HDL- cholesterol (mmol/l) | -1.125 (0.005) | -1.067 (0.166) | -1.076 (0.174) | -1.016 (0.807) |
| Fasting Blood Sugar (mmol/l) | 1.047 (0.092) | 1.079 (0.02) | -1.079 (0.028) | 1.023 (0.583) |
| Insulin (pmol/l) | 1.941 (1.2 × 10-4) | 1.614 (0.015) | -1.236- (0.312) | 1.288 (0.298) |
| Insulin Sensitivity (%) | -1.963 (1.1 × 10-4) | -1.637 (0.012) | 1.265 (0.266) | -1.294 (0.289) |
| Insulin Resistance | 1.393 (2.2 × 10-4) | 1.318 (0.007) | -1.119 (0.305) | 1.135 (0.313) |
Result presented as b (P-value) assessed by linear regression, adjusted for age, gender and race. Bolt values are significant. b: coefficient for the relationship between the dependent variable "metabolic syndrome parameters" and the independent variable "fibrinolytic PAI-1 and tPA parameters". The positive sign of the coefficient implies a direct relationship, and the negative sing implies an inverse relationship.