Table 1. p15 and clusterin expression in human pituitary adenomas.
p15 n (%) | Clusterin n (%) | |||||||
Intensity (%) | 0–5 | 6–50 | 51–100 | 0–5 | 6–50 | 51–100 | ||
Tumor Types | n | n | ||||||
GH/PRL | 27 | 16(59) | 4(15) | 7(26) | 17 | 13(76) | 3(18) | 1(6) |
Gonadotroph | 43 | 8(18) | 5(12) | 30(70) | 36 | 1(3) | 2(6) | 33(92) |
ACTH | 14 | 2(14) | 1(7) | 11(79) | 10 | 1(10) | 0(0) | 9(90) |
Carcinoma | N/A | 12 | 9(76) | 2(16) | 1(8) | |||
Normal pituitary | 5 | 1(20) | 2(40) | 2(40) | 4 | 2(50) | 2(50) | 0(0) |
Protein distribution differences between GH/PRL and gonadotroph tumors, p = 0.0006 for p15, and p = 0.0001 for clusterin (Wilcoxon Rank Sum Test). N/A- not available.