Table I.
Baseline | Reperfusion |
P value (Reperfusion period) |
||||||
---|---|---|---|---|---|---|---|---|
Day 3 | Day 7 | Day 14 | Day 21 | Group effect | Time effect | Group x time | ||
Heart rate | ||||||||
Control | 263±11 | 292±10 | 261±10 | 264±8 | 266±14 | P<0.0001 | P=0.0742 | P=0.5930 |
Ivabradine | 255±8 | 234±10 | 229±13 | 216±9 | 214±9 | |||
Left ventricular diastolic volume (ml/kg) | ||||||||
Control | 0.74±0.07 | 0.92±0.07 | 1.10±0.14 | 1.13±0.10 | 1.37±0.11 | P=0.0452 | P=0.0019 | P=0.7138 |
Ivabradine | 0.82±0.06 | 1.16±0.06 | 1.17±0.06 | 1.29±0.07 | 1.42±0.10 | |||
Left ventricular systolic volume (ml/kg) | ||||||||
Control | 0.27±0.02 | 0.42±0.03 | 0.59±0.09 | 0.63±0.08 | 0.79±0.10 | P=0.0276 | P=0.0022 | P=0.2768 |
Ivabradine | 0.27±0.02 | 0.46±0.05 | 0.45±0.04 | 0.52±0.03 | 0.59±0.05 |
Values are mean ± SEM.