Table 2.
Summary of targeted toxicities for diffuse intrinsic pontine glioma stratum
| Toxicity | Chemoradiotherapy (n = 58) | Maintenance (n = 49) |
|---|---|---|
| Allergic reaction/hypersensitivity | 0 | 8 |
| Anemia | 5 | 13 |
| Leukocytes (total white blood cell count) | 10 | 35 |
| Lymphopenia | 38 | 39 |
| Neutrophils/granulocytes | 10 | 47 |
| Thrombocytopenia | 9 | 34 |
| Nausea | 3 | 8 |
| Vomiting | 3 | 7 |
| Alanine aminotransferase level | 0 | 4 |
| Febrile neutropenia (fever of unknown origin) | 0 | 4 |
| Infection with grade 3 or 4 neutropenia | 2 | 5 |
| Infection with unknown ANC | 5 | 0 |
| Infection without neutropenia | 9 | 8 |
| Neuropathy | ||
| Cranial | 12 | 35 |
| Motor | 17 | 46 |
| Neurology | ||
| Sensory | 5 | 7 |
| Seizures | 0 | 3 |
Data are percentage of grade 3 or 4 toxicities for chemoradiotherapy and maintenance courses.