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. Author manuscript; available in PMC: 2012 Mar 25.
Published in final edited form as: J Nat Prod. 2011 Jan 6;74(3):526–536. doi: 10.1021/np1008152

Figure 3.

Figure 3

Schematic representation of the three potential scenarios for bithiazole vs. thiazolinyl-thiazole formation in the BLM/TLM and ZBM biosynthetic pathways, respectively. (A) Non-visible difference between twice-acting Ox domain in BlmIII/TlmIII and single-acting Ox domain in ZbmIII with additional epimerase accounting for change in configuration. (B) Single-acting Ox domain in BlmIII/TlmIII and ZbmIII with an additional oxidase in BLM/TLM biosynthesis and an additional epimerase in ZBM biosynthesis. (C) Twice-acting Ox domain in BlmIII/TlmIII and ZbmIII with additional reductase in ZBM biosynthesis.