Figure 2.

Schematic representation of the algorithms for each method implemented in seqMINER. In both methods, prior to quantification, reads are extended from a user-defined value (default 200 bp). (A) Density array method: a user defined number of bins are created in a fixed window around the reference coordinate and for each bin the maximal number of overlapping reads is computed in each dataset, the collected values are pooled and submitted to clustering process and the generated clusters are visualized as heatmap. (B) Enrichment based method: the number of tags presents or overlapping a user-defined window (default 2 kb) around the reference site are counted. The values from the different datasets are computed and ploted.