Table 3.

Thermodynamic parameters calculated from van’t Hoff plots.

Collision Complex	aΔG° (kcal·mol−1)	bΔH° (kcal·mol−1)	cΔS° (cal·mol−1)	TΔS° (kcal·mol−1)
Kligand (k+ligand/k−ligand)	−7.8 ± 0.1	−5.0 ± 0.5	9.2 ± 1.6	−2.7 ± 0.5
Pocket Conformational Change
Kpocket (k+pocket/k−pocket)	0.9 ± 0.2	−5.8 ± 1.3	−22.6 ± 4.5	6.7 ± 1.3

^aDetermined from Eq. 13

^bDetemined from Eq. 14

^cDetermined from Eq. 15