Table 2.

Otoconia/otolith component proteins identified to date. Bolded ones are identified and validated in the present study.

	Presence in Otoconia	Otoconia phenotype	References
	Otoconin-90 (Oc90)	Giant otoconia	Zhao et al., 2007
	Otolin-1	---	---
Mouse	Osteopontin	Normal otoconia	Zhao et al., 2008
	Fetuin-A	Normal otoconia?	Zhao et al., 2007; Thalmann et al., 2006
	Sparc-like 1 (Sc1)	---	---
	Sparc	---	---
	KSPG	---	---
	DMP1	---	---
	α-tectorin	Reduced otoconia layer	Legan et al., 2000
	Otolith matrix protein	Residual seeding	Murayama et al., 2004
Fish	Otolin-1	Fused, unstable	Murayama et al., 2004
	Starmaker	Inorganic, calcite	Sollner et al., 2003
	Sparc	Small otoliths	Kang et al,, 2008
	Otoc1 (zOc90)	Small otoliths	Petko et al,, 2008
	Matrix macromolecule-64	---	---
	Precerebellin-like (Cbln1)	---	---
	Neuroserpin	---	---

---, no mutant available or unknown otoconia/otolith phenotype.