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TLR-induced production of hematopoietic growth factors by naive and memory B cells. Purified B cells were further separated into naive (CD27-) and memory (CD27+) B cells and stimulated with TLR ligands as described in Fig. 1. TLR1/TLR2 and TLR7 induced G-CSF and GM-CSF secretion almost exclusively by memory B cells. TLR9 stimulations did not induce secretion of either growth factor
