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Development of CKD after ureteral obstruction. a WT and S100A12tg (TG) mice had the right ureter obstructed (RUO) for 6 days followed by the release of obstruction (RRUO), 7 days of recovery and then removal of contralateral kidney function by left ureteral obstruction (LUO). BUN levels were measured post-LUO to assess function of the previously obstructed kidney. b Serum S100A12 was measured in WT and S100A12tg mice at sacrifice. ∗ p < 0.01.
