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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2010 Feb 2;3(2):187–198. doi: 10.1161/CIRCGENETICS.109.904813

Figure 2A. TH promoter haplotype activities. Statistical analyses were based on results from 8 naturally occurring haplotypes (haplotypes 1, 2, 3, 7, 8, 9, 11, and 13; on-line supplemental Table 1).

Figure 2A

Basal activity.

Left panel: Haplotype effects. Differential luciferase reporter activity in transfected pheochromocytoma (PC12) cells. Here only the 3 most common haplotypes (frequency ≥10%) are shown, based on the 4 common promoter variants: C-824T, G-801C, A-581G, and G-494A. ANOVA is shown for haplotype number as the independent variable. Results of ANOVA are shown for the haplotype as the independent variable, and luciferase activity as the dependent variable.Right panel: Individual SNP effects. Results of ANOVA are shown for the individual SNP as the independent variable, with luciferase activity as the dependent variable. A −log[10]p value plot is shown for significance of each of the 4 common variants.