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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Brain Behav Immun. 2010 Oct 15;25(5):932–937. doi: 10.1016/j.bbi.2010.10.001

Figure 1. EAE mediated by IL-23 polarized cells is independent of IL-17 signaling.

Figure 1

Lymph nodes were harvested from WT mice that had been immunized 10 days earlier with MOG35–55+CFA. (A) Whole lymph node cells were stimulated with MOG35–55 and IL-23 for 4 days. Afterwards CD4+ T cells were isolated and transferred to either WT or IL-17R −/− naïve recipients (5×106 cells/host i.p.). (B) WT (left) or IL-17R −/− (right) mice that received Th17 polarized CD4+ T cells were sacrificed at peak disease. CNS specimens were harvested, fixed, sectioned, and stained with H&E. Upper panels, magnification 4×; lower panels, 40×. Bar 50µm. Data are representative of 4 independent experiments with 5–7 mice/group.