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DNGR-1 targeting leads to limited antigen-specific Ab production in the absence of adjuvant WT (A–C) or DNGR-1 KO (B) mice were injected with 0.5 μg (A, B) or with the indicated amounts (C) of anti-DNGR-1 or isotype-matched control mAb in the presence/absence of 40 μg of poly I:C. Anti-rat IgG serum Ab titers were determined (A, B) at the indicated time points or (C) 20 days after immunization. Data are the mean±SD of three mice from one experiment representative of two.
