Table 1.

Sensitivity and Specificity of Up24 for Infant HIV diagnosis using Receiver Operator Characteristics Curves (N=278)

Multiples of NCSDa for Cut-Point OD	Sensitivity (%)(95% CI)	Specificity (%)(95% CI)	AUCb	Correct Classification (%)
0	92.7(89.6–95.7)	46.8(41.0–52.7)	0.69	53.6
1	92.7(89.6–95.7)	58.2(52.4–64.0)	0.75	63.3
2	92.7(89.6–95.7)	65.4(59.8–70.9)	0.79	69.4
3	87.8(89.6–95.7)	74.3(69.1–79.4)	0.81	76.2
4	87.8(83.9–91.6)	81.4(76.8–86.0)	0.85	82.4
5	87.8(83.9–91.6)	86.5(82.5–90.5)	0.87	86.7
6	87.8(83.9–91.6)	89.9(86.3–93.4)	0.89	89.6
7	87.8(83.9–91.6)	91.6(88.3–94.8)	0.90	91.0
8c	87.8(83.9–91.6)	92.0(88.8–95.2)	0.90	91.4
9	80.5(75.8–85.1)	92.8(89.8–95.9)	0.87	91.0
10	80.5(75.8–85.1)	93.7(90.8–96.5)	0.87	91.7
11	80.5(75.8–85.1)	96.2(93.9–98.5)	0.88	93.9
12	80.5(75.8–85.1)	97.0(95.0–99.0)	0.89	94.6
13	80.5(75.8–85.1)	97.9(96.2–99.6)	0.88	95.0
14	78.0(73.2–82.9)	98.3(96.8–99.8)	0.88	95.3
15	78.0(73.2–82.9)	98.7(97.4–100.0)	0.88	95.7

^aNCSD – Standard deviation of negative controls per assay

^bAUC – Area under the receiver operating characteristic curve

^cMultiple of NCSD with maximum sensitivity and specificity