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Failure of combination treatment (AI with cytotoxic agent) to limit tumor growth when the cytotoxic agent is removed after six weeks and AI is removed after one year. (a) Area of active tumor region as a function of time. (b) Snapshot of growing tumor after 10 months of treatment with AI. (c) Snapshot of tumor three weeks after ending treatment with AI. (d) Snapshot of tumor four months after ending treatment with AI.
