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. 2011 Feb 14;127(3):511–528. doi: 10.1542/peds.2009-3592

TABLE 4.

Potential Pharmaceutical Supplement Interactions With Energy Drink Ingredients30,82,83

Energy Drink Ingredient Interactions
5-Hydroxy tryptophan Should not be combined with monoamine oxidase inhibitors
Vinpocetine Increases the risk for excessive bleeding and should not be combined with aspirin, clopidogrel, warfarin, pentoxifylline, vitamin E, garlic, and gingko
Yohimbine Affects cardiac function and should not be combined with tricyclic antidepressants, bupropion, phenothiazines, clonidine, stimulants, decongestants, or other blood pressure-lowering medications
Ginseng Prolongs bleeding time and should not be combined with warfarin; interacts with phenelzine sulfate in patients being treated for mania; may interfere with estrogens or corticosteroids; may impede digoxin metabolism; reduces blood glucose levels