TABLE 1.
Baseline Characteristics of the 16-Year-Old Cohort
| Preterm | Term | |
|---|---|---|
| No. subjects at inception | 505 | — |
| Proportion surviving to NICU discharge, n (%) | 446 (88%) | — |
| Proportion surviving to 16 y, n (%) | 437 (87%) | — |
| Follow-up at 16 y (%) | 337 (77%) | 102 |
| Child characteristics | ||
| Gestational age, mean (SD) | 28 (2) | — |
| Birth weight, mean (SD) | 961 (173) | — |
| Small for gestational age, n (%) | 79 (23%) | — |
| Male gender, n (%) | 178 (53%) | 49 (48%) |
| Multiple births, n (%) | 71 (21%) | — |
| Antenatal steroids, n (%) | 113 (34%) | — |
| Prophylactic indomethacin, n (%)a | 162/329 (49%) | — |
| Severe brain injury,bn (%) | 31/334 (9%) | — |
| Grade 3–4 intraventricular hemorrhage | 11 (3%) | |
| Periventricular leucomalacia | 17 (5%) | |
| Grade 2 and higher ventriculomegaly | 17 (5%) | |
| O2 at 28 d, n (%) | 155/336 (46%) | — |
| Neurosensory impairment, n (%) | 50 (15%) | 0 |
| Cerebral palsyc | 30 (9%) | |
| Hearing aids | 8 (2%) | |
| Services for the blind | 10 (3%) | |
| Seizure disorder | 9 (3%) | |
| Ventriculoperitoneal shunt | 8 (2%) | |
| Social factors | ||
| Maternal age at birth, mean (SD), y | 28 (6) | 30 (6) |
| Maternal education, mean (SD), y | 14 (2) | 15 (3) |
| Maternal education < high school, n (%) | 41 (12%) | 5 (5%) |
| Single-parent household, n (%) | 111 (33%) | 25 (25%) |
| Minority status of child by caregiver report (race and ethnicity), n (%) | 107 (32%) | 30 (29%) |
| Mean age at assessment, mean (SD), y | 16.1 (0.3) | 16.2 (0.3) |
| WISC-III FSIQ, mean (SD) | 88 (19) | 104 (16) |
| PPVT-R, mean (SD) | 95 (24) | 106 (21) |
a
Not all children were randomly assigned to receive prophylactic indomethacin.
b
Numbers do not add up to 31 because some children had more than 1 injury.
c
Among children with cerebral palsy, 9 had spastic diplegia, 4 had spastic hemiplegia, and 17 had spastic quadriplegia.