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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: Mol Cell. 2009 Jul 31;35(2):141–142. doi: 10.1016/j.molcel.2009.07.005

Figure 1.

Figure 1

Scheme for the Ras-mediated inactivation of FAK. Activated Ras, signaling through Cdc42, PAK1 and MEK, leads to an ERK-induced phosphorylation of FAK at serine 910. This phosphorylation event triggers the binding of PIN1 to FAK which in turn leads to the recruitment of PTP-PEST to FAK. PTP-PEST then de-phosphorylates tyrosine 397 on FAK, a FAK-autophosphorylation site that is crucial for its signaling functions. Surprisingly, it is the resulting inactivation of FAK that appears to be necessary for Ras-stimulated cell migration and invasion.