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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: Gut. 2008 Oct 2;58(1):60–67. doi: 10.1136/gut.2008.156422

Figure 5. Down-regulation of NF-κB activation in B cell lines from Crohn’s Disease patients with anti-CBir1 related NFKB1 haplotype.

Figure 5

Figure 5

Haplotype specific B cell lines were prepared from peripheral blood of CD patients. EMSA analysis was performed in non H1/non H1 (n = 24) including H3/H3 and H3/X (non H1) (n = 11) and H1/H1 and H1/X (non H3) (n = 14). (A) NF-κB-specific band from H3/H3 and H1/H1 was shown. (B) Densitometric readings were obtained. The median NF-κB relative expression was lower for H1/H1 and H1/X (closed circle) (1.28) compared to non H1 (closed and opened triangle). The median NF-κB relative expression was lower for H1/H1 and H1/X (1.28) compared to H3/H3 and H3/X (opened triangle). All P-values are generated by Wilcoxon test.