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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: Neuropsychopharmacology. 2008 Feb 20;33(11):2586–2594. doi: 10.1038/sj.npp.1301674

Figure 6. Cardiovascular and behavioral responses to lactate following the BNST priming.

Figure 6

Five daily injections of Ucn1 into the BNST induced a significant reduction in social interaction (SI: see Panel A), whereas 3 daily injections did not (data not shown, see results). Infusion of sodium lactate (0.5M, 10ml/kg) did not further suppress SI in 5 day (Panel A) or 3 day (data not shown, see results) Ucn1 primed rats. The (*) indicates a significant difference in SI from the baseline (p<0.05), and the (#) represents a significant difference from lactate baseline (p<0.05). Neither sodium lactate nor saline infusion (intravenous: i.v.) altered heart rate (HR) or mean arterial pressure responses (MAP) in 5 day (Panel B) or 3 day (data not shown, see results) Ucn1 treated rats. Analyses were done on within subjects time effects (which were the difference in the change in HR or MAP from the mean of the 5 min baseline) and between subjects effects at each individual time point.