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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: J Psychopharmacol. 2008 Feb 28;22(6):633–641. doi: 10.1177/0269881107082902

Figure 5.

Figure 5

Changes in A) social interaction time, B) heart rate, C) blood pressure and D) respiration rate in rats infused with i.v. sodium lactate prior to L-AG pump placement in the BNST, and on day 20 or 22 after beginning infusions with the GABA synthesis inhibitor L-AG and pre-injections of either saline or muscimol 100 pmoles into the BNST. There were no significant peripheral responses to lactate infusions in these animals either at baseline or after GABA synthesis inhibition in the BNST which resulted in increased baseline anxiety. In these animals, there was no difference in lactate responses after saline or muscimol pre-injections into the BNST, suggesting no differences in lactate sensitivity with or without baseline anxiety increases. * significant against pre L-AG in BNST (*, paired t-test, p<0.002) and L-AG in BNST + 100 pmoles muscimol (*, paired t-tests, p≤0.050). Bars represent the mean and error bars represent the SEM.