Table 3.
Differential effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue fever and dengue hemorrhagic fever.
| Dengue fever (GMT and ranges, pg/mL) | DHF (GMT and ranges, pg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Doxycycline | Tetracycline | Doxycycline | Tetracycline | |||||
| Day 3 | Day 7 | Day 3 | Day 7 | Day 3 | Day 7 | Day 3 | Day 7 | |
|
| ||||||||
| IL-6 | 5.98† | 3.96* | 6.36 | 5.48 | 3.84* | 2.36* | 4.68 | 4.23 |
| (3.70–7.98) | (2.32–6.89) | (4.72–7.90) | (3.89–7.07) | (2.01–6.73) | (1.24–5.38) | (2.93–6.98) | (2.46–6.66) | |
| IL-1β | 2.29* | 1.55* | 3.36 | 2.23 | 5.32* | 3.29* | 7.68 | 7.22 |
| (1.23–4.12) | (1.10–2.78) | (1.48–5.43) | (1.02–4.69) | (3.21–8.53) | (1.21–6.48) | (5.59–9.44) | (5.21–9.32) | |
| IL-1 RA | 673* | 964* | 330 | 404 | 710* | 996* | 517 | 510 |
| (486–851) | (701–1459) | (201–732) | (231–920) | (462–928) | (703–1532) | (342–695) | (342–714) | |
| TNF | 2.42* | 0.90* | 3.89 | 3.31 | 5.31* | 4.31* | 7.83 | 7.54 |
| (0.23–4.63) | (0.4–3.02) | (2.03–5.65) | (1.19–5.08) | (0.46–12.32) | (1.04–7.94) | (5.99–9.62) | (5.71–9.17) | |
| TNF R1 | 2432* | 2616€ | 2115 | 2324 | 1961* | 2367* | 1736 | 1853 |
| (673–3762) | (1021–4412) | (1358–3282) | (1409–3974) | (1538–2985) | (1759–3129) | (1329–2116) | (1365–2362) | |
€(P < .05).
*(P < .01).
†(P > .05).