Table 3.
Risk of stroke, sudden death, MI, death caused by CHF, combined CVEs, and all-cause mortality per unit increase in copeptin (continuous variable, log-transformed)
| Outcome | HR and 95% CI |
||
|---|---|---|---|
| Crude | Adjusted | Adjusteda | |
| Stroke | 1.73 | 1.74 | 1.62 |
| (1.25 to 2.39) | (1.23 to 2.47) | (1.11 to 2.36) | |
| P < 0.001 | P = 0.002 | P = 0.012 | |
| Sudden death | 1.49 | 1.44 | 1.33 |
| (1.16 to 1.92) | (1.10 to 1.91) | (0.99 to 1.80) | |
| P = 0.002 | P = 0.009 | P = 0.059 | |
| MI | 1.05 | 1.00 | 0.99 |
| (0.85 to 1.30) | (0.79 to 1.25) | (0.77 to 1.26) | |
| P = 0.627 | P = 0.964 | P = 0.90 | |
| Death caused by CHF | 1.53 | 1.33 | 1.37 |
| (0.93 to 2.53) | (0.75 to 2.36) | (0.74 to 2.55) | |
| P = 0.098 | P = 0.332 | P = 0.323 | |
| Combined CVEb | 1.32 | 1.24 | 1.18 |
| (1.14 to 1.52) | (1.06 to 1.45) | (1.00 to 1.40) | |
| P < 0.001 | P = 0.008 | P = 0.052 | |
| All-cause death | 1.30 | 1.29 | 1.18 |
| (1.15 to 1.50) | (1.12 to 1.48) | (1.02 to 1.36) | |
| <0.001 | P < 0.001 | P = 0.032 | |
aFurther adjustment for markers of volume status and residual urine output.
bMI, cardiac death, and stroke.