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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Rev Clin Oncol. 2010 Sep 14;7(11):653–664. doi: 10.1038/nrclinonc.2010.139

Figure 6.

Figure 6

Mean interstitial pH and pO2 as a function of the distance to the nearest blood vessel. Please note the low pH and low pO2 only becomes significantly low beyond 100 µm from a blood vessel wall. Thus, pH sensitive particles need to penetrate beyond 100 µm to take advantage of the low pH. Permission obtained from Nature Publishing Group © Helmlinger, G. et al. Nat. Med. 3, 177–182 (1997). Abbreviation: pO2, partial oxygen pressure.