Table 5.
Sleep architecture and effects of supine position and REM sleep (mITT analysis) week 1 results.
| EPAP |
Sham |
P Value | |||
|---|---|---|---|---|---|
| Device-off | Device-on | Device-off | Device-on | EPAP vs Sham (absolute change) | |
| N = 92 |
N = 81 |
||||
| TST | 364.0 ± 56.7 | 352.4 ± 65.1 | 357.6 ± 73.4 | 344.4 ± 66.2 | 0.87 |
| Wake After Sleep Onset | 57.6 ± 42.4 | 54.0 ± 36.8 | 57.3 ± 43.3 | 58.8 ± 37.8 | 0.43 |
| Stage N1 | 16.9 ± 10.6 | 14.5 ± 8.6** | 17.6 ± 12.6 | 19.0 ± 13.1 | 0.034 |
| Stage N2 | 60.4 ± 10.1 | 62.7 ± 8.8** | 59.7 ± 10.1 | 59.9 ± 11.6 | 0.22 |
| Stage N3 | 5.4 ± 6.5 | 5.7 ± 6.6 | 5.8 ± 6.3 | 4.7 ± 5.0 | 0.071 |
| Stage REM | 17.3 ± 5.8 | 17.1 ± 6.4 | 17.0 ± 6.0 | 16.4 ± 6.1 | 0.88 |
| Arousal Index | 19.9 (13.5, 28.8) | 15.3* (11.7, 22.5) | 20.2 (13.9, 26.2) | 19.2 (15.0, 26.8) | < 0.001 |
| N = 85 |
N = 72 |
||||
| AHI NREM1 | 14.9 (7.7, 24.0 ) | 6.0* (1.7, 12.6) | 10.8 (5.4, 22.0) | 11.5 (5.0, 24.0) | < 0.001 |
| AHI REM1 | 26.5 (10.3, 45.1) | 8.7* (2.5, 27.9) | 31.6 (9.7, 46.9) | 22.4 (7.6, 43.2) | 0.003 |
| N = 57 |
N = 57 |
||||
| AHI Supine1 | 29.2 (18.2, 46.5) | 12.7* (3.3, 36.6) | 24.8 (14.7, 42.7) | 25.9 (12.8, 47.2) | 0.036 |
| AHI Non-Supine1 | 6.0 (2.4, 11.3) | 2.5** (0.7, 6.3) | 6.6 (1.9, 15.2) | 4.8 (2.1, 16.2) | 0.093 |
Values are median (25, 75 quartile) or, mean ± standard deviation.
*
Device-off versus Device-on P < 0.01.
**
Device-off versus Device-on P < 0.05.
1
Patients with > 20 minutes in each position and state.