Table 2. Statistical correlations between the immunointensity of ARMS and each clinicopathological characteristic in 54 patients with primary cutaneous melanoma.
|
Intensity of ARMS staining
|
||||||
|---|---|---|---|---|---|---|
| Negative | Weak | Moderate | Strong | Total | P-value a | |
| Age | ||||||
| ⩽64 | 2 (7.4%) | 11 (40.8%) | 10 (37.0%) | 4 (14.8%) | 27 | 0.86 |
| >64 | 1 (3.7%) | 9 (33.3%) | 12 (44.4%) | 5 (18.5%) | 27 | |
| Sex | ||||||
| Male | 2 (7.7%) | 10 (38.5%) | 8 (30.8%) | 6 (23.1%) | 26 | 0.098 |
| Female | 1 (3.6%) | 10 (35.7%) | 14 (50%) | 3 (10.7%) | 28 | |
| Tumour thickness (mm) | ||||||
| ⩽1.0 | 3 (20.0%) | 2 (13.3%) | 10 (66.7%) | 0 (0%) | 15 | 0.002b |
| >1.0 | 0 (0.0%) | 18 (46.1%) | 12 (30.8%) | 9 (23.1%) | 39 | |
| Ulceration | ||||||
| Absent | 3 (7.7%) | 16 (41.0%) | 17 (43.6%) | 3 (7.7%) | 39 | 0.053 |
| Present | 0 (0.0%) | 4 (26.7%) | 5 (33.3%) | 6 (40.0%) | 15 | |
| Lymph node invasion or distant metastasis | ||||||
| Negative | 3 (12.5%) | 6 (25.0%) | 13 (54.2%) | 2 (8.3%) | 24 | 0.026b |
| Positive | 0 (0.0%) | 14 (46.7%) | 9 (30.0%) | 7 (23.3%) | 29 | |
| Tumour subtype | ||||||
| ALM | 3 (7.1%) | 15 (35.7%) | 18 (42.9%) | 6 (14.3%) | 42 | 0.44 |
| NM | 0 (0.0%) | 3 (60.0%) | 0 (0%) | 2 (40.0%) | 5 | |
| SSM | 0 (0.0%) | 2 (28.6%) | 4 (57.1%) | 1 (14.3%) | 7 | |
Abbreviations: ALM=acral lentiginous melanoma: ARMS=ankyrin repeat-rich membrane spanning; NM=nodular melanoma; SSM=superficial spreading melanoma.
a
Fisher’s exact test;
b
P<0.05.