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. 2011 Mar 1;104(6):1013–1019. doi: 10.1038/bjc.2011.28

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Copyright © 2011 Cancer Research UK

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Transcriptional activation of DSC3 by p53. (A) Induction of DSC3 mRNA expression after transfection of the three colon cancer cell lines CX-2, WiDr, and HRT-18 with an expression vector encoding wild-type p53 was measured by quantitative RT–PCR. Mock transfectants (empty vector) were used as control. (B and C) P53-induced DSC3 expression was enhanced after DAC treatment in the cell lines WiDr and HRT-18. Parental cells were used as control. (D) Induction of DSC3 transcription by ADR, but not DAC, in the cell line CX-2. (E and F) Synergistic effect of combined ADR+DAC treatment on WiDr and HRT-18 cells, respectively.