Table 3. Magnitude of differential expression of OPN and coregulators between primary CRC and matched liver metastases.
| Colon (% positivity) | Liver (% positivity) | Matched pair difference | Paired t-test significance | |
|---|---|---|---|---|
| Negative control | 2.8±0.3 | 3.2±0.4 | 0.5±0.5 | 0.338 |
| OPN | 24.4±2.4 | 11.7±1.1 | −12.7±2.4 | <0.001 |
| Ets1 | 28.6±2.8 | 59.4±2.2 | 30.8±3.2 | <0.001 |
| Ets2 | 57.8±2.0 | 64.2±2.7 | 6.4±3.4 | 0.07 |
| PEA3 | 25.4±2.0 | 44.2±3.1 | 18.8±3.3 | <0.001 |
| Tcf4 | 37.3±3.7 | 48.4±2.7 | 11.1±4.0 | 0.009 |
| β-catenin | 52.7±2.0 | 62.6±3.1 | 9.9±3.3 | 0.006 |
| β-Cat/Tcf4 ratio | 70.8±6.9 | 79.7±5.1 | −8.9±8.1 | 0.283 |
Abbreviations: CRC=colorectal cancer; OPN=osteopontin.