Table 5. Differential expression of OPN and coregulators between primary and secondary CRC: prognostic significance.
|
95% CI for Exp (B)
|
|||||
|---|---|---|---|---|---|
| Marker | Mean colon to liver ratio (95% CI) | Hazard ratio Exp (B) | Lower | Upper | Significant P-value |
| OPN | 3.15 (1.54, 4.75) | 1.145 | 1.002 | 1.308 | 0.047 |
| β-catenin | 0.92 (0.74, 1.10) | 5.950 | 0.471 | 75.175 | 0.168 |
| Ets1 | 0.50 (0.39, 0.62) | 0.408 | 0.031 | 5.305 | 0.493 |
| Ets2 | 1.00 (0.77, 1.22) | 0.259 | 0.030 | 2.249 | 0.221 |
| PEA3 | 0.68 (0.48, 0.87) | 0.686 | 0.136 | 3.449 | 0.647 |
| Tcf4 | 0.85 (0.066, 1.04) | 4.520 | 0.817 | 24.991 | 0.084 |
Abbreviations: CI=confidence interval; CRC=colorectal cancer; CRLM=colorectal liver metastases; OPN=osteopontin.
The prognostic significance of differential expression of OPN and coregulators between primary CRC and liver metastases was assessed by a Cox multivariate proportionate hazard method. Outcomes are expressed as a Hazard ratio (Exp B), which describes effects of a unit increase in colon to liver ratio for each marker on relative risk of death at time t, together 95% CIs and significance of the association. The ratio of OPN expression between paired samples of primary CRC and CRLM had prognostic significance after liver resection.