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. 2011 Feb 15;104(6):989–999. doi: 10.1038/bjc.2011.34

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Copyright © 2011 Cancer Research UK

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CA125/MUC16 knockdown disrupts cell–cell junctions. (A) Assessment of cell–cell junctions in Ctrl scFv and CA125/MUC16 knockdown cells and OSE cells by electronic microscopy. Arrows indicate the presence of three desmosome spots in Ctrl scFv cells and the lack of such desmosomes in knockdown cells (scale bar – 100 nm). (B) Immunofluorescence analysis of claudin-7 expression, a protein involved in tight junctions, in Ctrl scFv and knockdown cells showing the disruption of the protein at the cell surface of knockdown cells ( × 1000 magnification).