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. 2011 Feb 15;104(6):989–999. doi: 10.1038/bjc.2011.34

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Copyright © 2011 Cancer Research UK

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CA125/MUC16 knockdown increases the invasive phenotype. (A) Matrigel-coated Boyden's chamber were used to assess the effect of CA125/MUC16 knockdown on invasive property of NIH:OVCAR3. CA125/MUC16 knockdown cells exhibited a significant increase in invasiveness compared with parental NIH:OVCAR3 and Ctrl scFv cells (P<0.001; × 100 magnification). (B) Secreted MMP-2 and MMP-9 activities in cell-free conditioned medium is increased in CA125/MUC16 knockdown cells compared with control NIH:OVCAR3 and Ctrl scFv cells. Blood was used as a positive control of MMP-2 and MMP-9 activity.