Table 3. Nucleotide polymorphisms in CRC patients and potentially related miRNAs.
| db SNP ID | Location | Variation (M/m) | Potentially related miRNA | Remark | Reference |
|---|---|---|---|---|---|
| rs17281995 | 3′UTR of CD86 | G/C | miR-337 miR-582 miR-200a* | Associated with increased risk of CRC in Caucasians | Landi et al (2008) |
| rs1051690 | 3′UTR of INSR | G/A | miR-612 miR-618 | Associated with increased risk of CRC in Caucasians | Landi et al (2008) |
| — | Position 90 in uc.276 | A/G | miR-214 miR-887 | Rare polymorphism found in CRC patients | Wojcik et al (2010) |
| rs11077 | 3′UTR of XPO5 | A/C | — | Weak associated with DCR; not associated with survival | Boni et al (2010); Lee et al (2010) |
| rs7372209 | 5′UTR of pri-miR-26a-1 | C/T | miR-26a-1 | Significantly associated with ORR and TTP; not associated with survival | Boni et al (2010); Lee et al (2010) |
| rs1834306 | 5′UTR of pri-miR-100 | C/T | miR-100 | Weak associated with TTP; not associated with survival | Boni et al (2010); Lee et al (2010) |
Abbreviations: CRC=colorectal cancer; DCR=disease control rate; ORR=overall response rate; M=major allele; m=minor allele; miRNA=microRNA; SNP=single-nucleotide polymorphism; TTP=time to progression; UTR=untranslated region.