Table 2.
Exercise Performance
| Exercise | Control | P-Value | |||
|---|---|---|---|---|---|
| Baseline | Final | Baseline | Final | ||
| Peak Exercise (Bike) | |||||
| Indexed VO2 (ml/kg/min) | 13.8 ± 2.5 | 16.1 ± 2.6 | 12.8 ± 2.6 | 12.5 ± 3.4 | 0.0001 |
| VO2 (ml/min) | 1073 ± 255 | 1259 ± 316 | 991 ± 225 | 958 ± 259 | 0.0002 |
| Time (min) | 6.8 ± 2.3 | 8.2 ± 2.2 | 6.2 ± 1.9 | 5.6 ± 2.1 | 0.0001 |
| Workload (Watts) | 51 ± 18 | 61 ± 18 | 45 ± 15 | 44 ± 15 | 0.0007 |
| Heart rate (bpm) | 133 ± 20 | 137 ± 16 | 136 ± 18 | 129 ± 20 | 0.02 |
| Heart rate reserve (bpm) | 64 ± 24 | 68 ± 17 | 64 ± 17 | 57 ± 17 | 0.004 |
| Systolic BP (mmHg) | 185 ± 27 | 186 ± 21 | 185 ± 28 | 175 ± 28 | 0.04 |
| Diastolic BP (mmHg) | 88 ± 8 | 88 ± 9 | 86 ± 12 | 84 ± 11 | 0.31 |
| Respiratory rate (bpm) | 33 ± 7 | 37 ± 6 | 36 ± 7 | 37 ± 7 | 0.005 |
| Oxygen pulse (ml/beat) | 8.1 ± 1.7 | 9.2 ± 2.0 | 7.2 ± 1.6 | 7.4 ± 1.8 | 0.02 |
| VCO2 (ml/min) | 1181 ± 321 | 1414 ± 354 | 1089 ± 277 | 1036 ± 345 | 0.0001 |
| VE (l/min) | 45 ± 13 | 53 ± 14 | 42 ± 12 | 39 ± 13 | 0.0001 |
| RER | 1.12 ± 0.09 | 1.15 ± 0.09 | 1.12 ± 0.10 | 1.10 ± 0.11 | 0.07 |
| VE/VCO2 slope | 34 ± 6 | 35 ± 8 | 33 ± 5 | 34 ± 5 | 0.44 |
| VAT (ml/min) | 746 ± 149 | 822 ± 180 | 660 ± 174 | 618 ± 126 | 0.001 |
| 6 Minute walk (feet) | 1494 ± 224 | 1659 ± 173 | 1412 ± 382 | 1460 ± 411 | 0.002 |
Data represent means ± SD; p-value represents comparison of least square means at final visit following adjustment for baseline values. Abbreviations: VO2: oxygen consumption; VCO2: VE: minute ventilation; carbon dioxide production; RER: respiratory exchange ratio; VAT: ventilatory anaerobic threshold; BP: blood pressure