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. 2001 Mar 13;98(6):3328–3333. doi: 10.1073/pnas.041614798

Figure 3.

Figure 3

Effects of hMCIP1 on cardiac hypertrophy induced by activated calcineurin. (A) Gross morphology of hearts from wild-type, α−MHC-hMCIP1 transgenic, α−MHC-CnA* transgenic, and doubly transgenic (α−MHC-hMCIP1 × α−MHC-CnA*) mice aged 20 weeks. (B) M-mode echocardiographic analysis from male littermates of the indicated genotypes at an age of 20 weeks. Heart rate was markedly slowed in the α-MHC-CnA* animals relative to mice of other genotypes. Echocardiographic measurements of these animals are found in Table 2. (C) RNA dot blot analysis of gene expression of GAPDH, α-MHC, β-MHC, α-skeletal actin, and ANF in hearts of mice of the indicated genotypes.